Cascade synthesis of indolizines and pyrrolo[1,2-a]pyrazines from 2-formyl-1-propargylpyrroles-Reference-Cited by-同舟云学术

Cascade synthesis of indolizines and pyrrolo[1,2-a]pyrazines from 2-formyl-1-propargylpyrroles

Published:2022 Issue:2 Volume:20 Page:396-409
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Escalante Carlos H.¹^ORCID,Carmona-Hernández Fernando A.¹,Hernández-López Alberto¹^ORCID,Martínez-Mora Eder I.¹²,Delgado Francisco¹,Tamariz Joaquín¹^ORCID

Affiliation:

1. Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, 11340 Mexico City, Mexico

2. Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza e Ing. J. Cárdenas S/N, 25280 Saltillo, Coah., Mexico

Abstract

A cascade reaction of 2-formyl-N-propargylpyrroles or N-allenyl-2-formylpyrroles with active methylene compounds and ammonium acetate provides indolizines and pyrrolo[1,2-a]pyrazines, respectively.

Funder

Consejo Nacional de Ciencia y Tecnología

Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional

Secretaría de Educación Pública

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB01839F

Reference71 articles.

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3. Indolizine: a biologically active moiety

4. Recent progress in synthesis and bioactivity studies of indolizines

5. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

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