Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors

Author:

Di Carluccio Cristina1,Forgione Rosa Ester1,Bosso Andrea2,Yokoyama Shinji3,Manabe Yoshiyuki3ORCID,Pizzo Elio2,Molinaro Antonio13,Fukase Koichi3,Fragai Marco45ORCID,Bensing Barbara A.67,Marchetti Roberta1,Silipo Alba1ORCID

Affiliation:

1. Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126, Naples, Italy

2. Department of Biology, University of Naples Federico II, Via Cinthia 4, 80126, Naples, Italy

3. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan

4. Magnetic Resonance Center (CERM), University of Florence, and Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

5. Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy

6. Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, California 94121, USA

7. Northern California Institute for Research and Education, San Francisco, California 94121, USA

Abstract

We here present a detailed molecular description of sialoglycans recognition by Siglec-like adhesins from S. gordonii opening the venue for the design of specific inhibitors to influence the propensity of streptococci to cause infective endocarditis.

Funder

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

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