Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors

Published:2017 Issue:82 Volume:7 Page:52180-52186
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wu Yichao¹²³⁴⁵,Dai Weichen¹²³⁴⁵,Chen Xin¹²³⁴⁵,Geng Aixin¹²³⁴⁵,Chen Yadong⁶²³⁴⁵,Lu Tao¹²³⁴⁵,Zhu Yong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Organic Chemistry

2. School of Science

3. China Pharmaceutical University

4. Nanjing 211198

5. China

6. Laboratory of Molecular Design and Drug Discovery

Abstract

A novel design approach by combination of PI3K and HDAC inhibitory activity in one molecule to produce dual inhibitors.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA08835C

Reference26 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. PI3K-Akt pathway: Its functions and alterations in human cancer

3. Targeting the phosphoinositide 3-kinase pathway in cancer

4. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110α inhibitors

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives;European Journal of Medicinal Chemistry;2024-11

2. The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods;Pharmaceuticals;2024-05-10

3. Molecular hybridization: a powerful tool for multitarget drug discovery;Expert Opinion on Drug Discovery;2024-03-08

4. Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects;European Journal of Medicinal Chemistry;2024-02

5. Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia;European Journal of Medicinal Chemistry;2024-01