Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia-Reference-Cited by-同舟云学术

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Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia

Published:2024-01 Issue: Volume:264 Page:116015
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhang Kehui,Huang Rui,Ji Ming,Lin Songwen,Lai Fangfang,Wu Deyu,Tian Hua,Bi Jinhui,Peng Shouguo,Hu Jiaqi,Sheng Li,Li Yan,Chen Xiaoguang,Xu Heng

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference47 articles.

1. Towards precosion medicine for AML;Döhner;Nat. Rev. Clin. Oncol.,2021

2. Distinguishing AML from MDS: a fixed blast percentage may no longer be optimal;Estey;Blood,2022

3. The clinical impact of the molecular landscape of acute myeloid leukemia;Kayser;Haematologica,2023

4. Acute myeloid leukaemia;Short;Lancet,2018

5. Emerging agents and regimens for AML;Liu;J. Hematol. Oncol.,2021

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1. The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods;Pharmaceuticals;2024-05-10

2. Chromatin modifiers in human disease: from functional roles to regulatory mechanisms;Molecular Biomedicine;2024-04-08

3. Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate;RSC Medicinal Chemistry;2024

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