O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents-Reference-Cited by-同舟云学术

O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents

Published:2015 Issue:4 Volume:6 Page:719-726
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Karamtzioti Paraskevi¹²³⁴⁵,Papastergiou Asterios¹²³⁴⁵,Stefanakis John G.⁶⁷⁸⁹¹⁰,Koumbis Alexandros E.⁶⁷⁸⁹¹⁰,Anastasiou Ioanna¹²³⁴⁵,Koffa Maria¹²³⁴⁵,Fylaktakidou Konstantina C.¹²³⁴⁵

Affiliation:

1. Laboratory of Organic

2. Bioorganic and Natural Product Chemistry

3. Molecular Biology and Genetics Department

4. Democritus University of Thrace

5. University Campus

6. Laboratory of Organic Chemistry

7. Chemistry Department

8. Aristotle University of Thessaloniki

9. Thessaloniki

10. Greece

Abstract

Pyridine oxime esters are effective DNA photocleavers, causing single-/double-stranded DNA cleavage at concentrations as low as 1 μM.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00548A

Reference92 articles.

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2. W. D. Wilson and F. A.Tanious, Molecular aspects of anticancer drug–DNA Interactions, ed. S. Neidle and M. J. Waring, Macmillan Press, Boca Raton FL, 1994, vol. 2, p. 243

3. Chemical nucleases

4. Charge transfer in DNA assemblies: effects of sticky ends

5. Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence

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