Fabrication and effect on regulating vSMC phenotype of a biomimetic tunica media scaffold

Author:

Shen Hong12345,Hu Xixue6758,Cui Haiyan91011128,Zhuang Yaping12345,Huang Da12345,Yang Fei12345,Wang Xing12345,Wang Shenguo12345,Wu Decheng12345

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. State Key Laboratory of Polymer Physics and Chemistry

3. Institute of Chemistry

4. Chinese Academy of Sciences

5. Beijing 100190

6. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety

7. National Center for Nanoscience and Technology

8. China

9. Ninth People's Hospital

10. School of Medicine

11. Shanghai Jiao Tong University

12. Shanghai 200011

Abstract

We constructed a bFGF@TGF-β1 loaded porous film-like PLGA scaffold with dual surface topography of nanofiber and micro-orientation structures for regulating the phenotype of vascular smooth muscle cell (vSMC).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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