Induction of apoptosis by cyclobutanones and derived polycyclic γ-lactones: a preliminary analysis of antiproliferative activity-Reference-Cited by-同舟云学术

Induction of apoptosis by cyclobutanones and derived polycyclic γ-lactones: a preliminary analysis of antiproliferative activity

Published:2015 Issue:9 Volume:6 Page:1626-1634
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sharma Vishal¹²³⁴⁵,Chaudhary Ashun⁶³⁴⁵,Chashoo Gousia⁷⁸⁹⁵,Arora Saroj⁶³⁴⁵,Saxena Ajit K.⁷⁸⁹⁵,Ishar Mohan Paul S.¹²³⁴⁵

Affiliation:

1. Bio-Organic and Photochemistry Laboratory

2. Department of Pharmaceutical Sciences

3. Guru Nanak Dev University

4. Amritsar 143 005

5. India

6. Department of Environmental and Botanical Sciences

7. Cancer Pharmacology Division

8. Indian Institute of Integrative Medicine

9. Jammu Tawi 180 001

Abstract

A series of cyclobutanones (7a–f) were synthesized by irradiation of β-ionone derived chalcones (4a–f) in aqueous methanol and further converted to polycyclic γ-lactones (8a–f) by Baeyer–Villiger oxidation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00289C

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4. (−)-Arctigenin as a Lead Structure for Inhibitors of Human Immunodeficiency Virus Type-1 Integrase

5. Novel Synthesis, Cytotoxic Evaluation, and Structure−Activity Relationship Studies of a Series of α-Alkylidene-γ-lactones and Lactams

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