Antibody–antigen complex modelling in the era of immunoglobulin repertoire sequencing-Reference-Cited by-同舟云学术

Antibody–antigen complex modelling in the era of immunoglobulin repertoire sequencing

Published:2019 Issue:4 Volume:4 Page:679-688
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Raybould Matthew I. J.¹²³⁴^ORCID,Wong Wing Ki¹²³⁴^ORCID,Deane Charlotte M.¹²³⁴^ORCID

Affiliation:

1. Department of Statistics

2. University of Oxford

3. Oxford

4. UK

Abstract

This review describes a pipeline to find antigen binders in large immunoglobulin gene sequencing datasetsviahigh-throughput antibody–antigen complex modelling.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2019/ME/C9ME00034H

Reference133 articles.

1. High-Throughput Sequencing of the Zebrafish Antibody Repertoire

2. Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires

3. Commonality despite exceptional diversity in the baseline human antibody repertoire

4. Third generation antibody discovery methods:in silicorational design

5. Five computational developability guidelines for therapeutic antibody profiling

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