Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example-Reference-Cited by-同舟云学术

Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example

Published:2017 Issue:5 Volume:7 Page:2435-2442
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ma Bing-Liang¹²³⁴⁵,Yang Yan¹²³⁴⁵,Dai Yan¹²³⁴⁵,Li Qiao¹²³⁴⁵,Lin Ge⁶⁷⁸⁹⁵,Ma Yue-Ming¹²³⁴⁵

Affiliation:

1. Department of Pharmacology

2. School of Pharmacy

3. Shanghai University of Traditional Chinese Medicine

4. Shanghai

5. China

6. School of Biomedical Sciences

7. Faculty of Medicine

8. The Chinese University of Hong Kong

9. Shatin

Abstract

High concentrations of PEG400 increase in vivo exposure to berberine (D) by increasing its solubility (A), permeability (B), and lymphatic transport (C).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA26284H

Reference52 articles.

1. Strategies to Address Low Drug Solubility in Discovery and Development

2. Polyethylene Glycol 400 Enhances the Bioavailability of a BCS Class III Drug (Ranitidine) in Male Subjects but Not Females

3. Pharmaceutical Excipients Influence the Function of Human Uptake Transporting Proteins

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