2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase-Reference-Cited by-同舟云学术

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

Published:2020 Issue:6 Volume:11 Page:707-731
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Matheson Christopher J.¹²³⁴⁵,Coxon Christopher R.¹²³⁴⁵^ORCID,Bayliss Richard⁶⁷⁸⁵⁹^ORCID,Boxall Kathy¹⁰¹¹¹²⁵,Carbain Benoit¹²³⁴⁵,Fry Andrew M.⁶⁷⁸⁵^ORCID,Hardcastle Ian R.¹²³⁴⁵,Harnor Suzannah J.¹²³⁴⁵^ORCID,Mas-Droux Corine⁹¹¹¹²⁵,Newell David R.¹¹³¹⁴¹⁵³,Richards Mark W.⁶⁷⁸⁵,Sivaprakasam Mangaleswaran¹²³⁴⁵,Turner David¹²³⁴⁵,Griffin Roger J.¹²³⁴⁵,Golding Bernard T.¹²³⁴⁵^ORCID,Cano Céline¹²³⁴⁵^ORCID

Affiliation:

1. Cancer Research UK Newcastle Drug Discovery Unit

2. Chemistry, School of Natural and Environmental Sciences

3. Newcastle University

4. Newcastle upon Tyne

5. UK

6. School of Molecular and Cellular Biology

7. The Astbury Centre for Structural Molecular Biology

8. University of Leeds

9. Section of Structural Biology

10. Cancer Research UK Cancer Therapeutics Unit

11. The Institute of Cancer Research

12. Sutton

13. Translational and Clinical Research Institute

14. Newcastle University Centre for Cancer

15. Faculty of Medical Sciences

Abstract

Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers.

Funder

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00074D

Reference36 articles.

1. Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

2. Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

3. Identification and Characterization of an Irreversible Inhibitor of CDK2

4. Gene Expression Profile of Serial Samples of Transformed B-Cell Lymphomas

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