Isolation and characterization of novel degradation products in cilnidipine by LC-QTOF-MS/MS, LCMSn, 2D-NMR and FTIR-Reference-Cited by-同舟云学术

Isolation and characterization of novel degradation products in cilnidipine by LC-QTOF-MS/MS, LCMSn, 2D-NMR and FTIR

Published:2018 Issue:1 Volume:42 Page:634-646
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Ch Krishnam Raju¹²³⁴⁵,J. V. Shanmukha Kumar¹²³⁴^ORCID,Goud Palusa Sanath Kumar⁵⁶⁷⁴

Affiliation:

1. Department of Chemistry

2. K L University

3. Guntur

4. India

5. Analytical Research and Development

6. United States Pharmacopeial Convention – India (P) Ltd.

7. Hyderabad

Abstract

Comprehensive stress studies performed for cilnidipine established 3D structures for novel degradants CD1 and CD2, which may be useful for drug discovery activities.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C7NJ02781H

Reference22 articles.

1. Antihypertensive effects of repeated oral administration of cilnidipine, a novel calcium antagonist, in 2K1C renal hypertensive dogs.

2. Study of the structures of photodegradation impurities and pathways of photodegradation of cilnidipine by liquid chromatography/Q-Orbitrap mass spectrometry

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