Isolation and characterization of novel degradation products in fenoverine by LC-QTOF-MS/MS, LC-MS<sup>n</sup> and 2D-NMR-Reference-Cited by-同舟云学术

Isolation and characterization of novel degradation products in fenoverine by LC-QTOF-MS/MS, LC-MSⁿ and 2D-NMR

Published:2024 Issue:21 Volume:48 Page:9589-9610
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Raju Ch Krishnam¹²^ORCID,Kumar J. V. Shanmukha¹^ORCID,Yesudas Kada³,Palusa Sanath Kumar Goud²

Affiliation:

1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, A.P.-522302, India

2. Analytical Research and Development, United States Pharmacopeial Convention – India (P) Ltd, Plot No. D6 & D8, IKP, Genome Valley, Shameerpet, Hyderabad, Telangana-500101, India

3. Synthetics Department, United States Pharmacopeial Convention – India (P) Ltd, Plot No. D6 & D8, IKP, Genome Valley, Shameerpet, Hyderabad, Telangana-500101, India

Abstract

Fenoverine was subjected to stress studies under various conditions to evaluate its degradation profile. The drug is highly susceptible to oxidative and alkaline stress conditions at room temperature, which resulted in five oxidative degradants and two alkaline degradants.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D3NJ05623F

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