Kinetic resolution of heterobiaryl <i>N</i>-oxides by asymmetric C–H olefination: an expeditious access to (<i>R</i>)-QUINAP-Reference-Cited by-同舟云学术

Kinetic resolution of heterobiaryl N-oxides by asymmetric C–H olefination: an expeditious access to (R)-QUINAP

Published:2023 Issue:20 Volume:10 Page:5210-5215
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Qi-Ying¹,Wang Hai-Yang¹,Wang Songlin¹,Ma Jing¹,Guo Hai-Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China

Abstract

A highly efficient kinetic resolution of heterobiaryl N-oxides through asymmetric C–H olefination was realized to provide two types of 1-arylisoquinoline N-oxides with excellent enantioselectivity (up to 97% ee and 99% ee, respectively).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01083J

Reference39 articles.

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4. Chiral Phosphoric Acid: A Powerful Organocatalyst for the Asymmetric Synthesis of Heterocycles with Chiral Atropisomerism

5. Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds

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