Synthesis of axially chiral biaryls <i>via</i> Pd(<scp>ii</scp>)-catalysed direct C(sp<sup>2</sup>)

Synthesis of axially chiral biaryls via Pd(ii)-catalysed direct C(sp²)–H arylation

Published:2024 Issue:18 Volume:11 Page:4986-4991
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Parmar Diksha¹²,Kumar Rohit¹²,Sarthi ¹,Sharma Akhilesh K.³^ORCID,Sharma Upendra¹²^ORCID

Affiliation:

1. C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur 176061, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

3. Institute of Chemical Research of Catalonia (ICIQ-CERCA), The Barcelona Institute of Science and Technology, Avgda. Països Catalans, 16, 43007 Tarragona, Spain

Abstract

Herein, a concise protocol for the construction of axially chiral biaryls via Pd-catalysed C–H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using a commercially available chiral mono-protected amino acid has been uncovered.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

University Grants Commission

Direcció General de Recerca de la Generalitat de Catalunya (General Directorate for Research in the Government of Catalonia) and managed by AGAUR (Gestió d’Ajuts Universitaris i de Recerca).

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00958D

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