Kaempferol fromPenthorum chinensePursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity-Reference-Cited by-同舟云学术

Kaempferol fromPenthorum chinensePursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity

Published:2020 Issue:9 Volume:11 Page:7925-7934
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Du Yi-Chao¹²³⁴²^ORCID,Lai Li⁴²³,Zhang Hao⁴²³,Zhong Fu-Rui⁴²³,Cheng Huan-Li⁴²³,Qian Bao-Lin⁴²³,Tan Peng¹²³⁴²,Xia Xian-Ming¹²³⁴²,Fu Wen-Guang¹²³⁴²^ORCID

Affiliation:

1. Academician (Expert) Workstation of Sichuan Province

2. the Affiliated Hospital of Southwest Medical University

3. China

4. Department of Hepatobiliary Surgery

Abstract

In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation.

Funder

Affiliated Hospital of Southwest Medical University

Southwest Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO00724B

Reference53 articles.

1. Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury

2. A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States