<i>N</i>-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells-Reference-Cited by-同舟云学术

N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells

Published:2023 Issue:44 Volume:14 Page:12498-12505
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Emms Vicki L.¹^ORCID,Lewis Liam A.¹^ORCID,Beja Lilla¹^ORCID,Bulman Natasha F. A.¹^ORCID,Pires Elisabete²^ORCID,Muskett Frederick W.³^ORCID,McCullagh James S. O.²^ORCID,Swift Lonnie. P.⁴^ORCID,McHugh Peter J.⁴^ORCID,Hopkinson Richard J.¹^ORCID

Affiliation:

1. Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK

2. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK

3. Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK

4. Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK

Abstract

N-Acyloxymethyl-phthalimides are esterase-sensitive chemical tools that enable controllable delivery of formaldehyde to human cells.

Funder

Wellcome Trust

Engineering and Physical Sciences Research Council

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02867D