Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism

Author:

John Tobias1ORCID,Saffoon Nadia1,Walsby-Tickle John1ORCID,Hester Svenja S.2,Dingler Felix A.3ORCID,Millington Christopher L.3,McCullagh James S. O.1,Patel Ketan J.3,Hopkinson Richard J.4ORCID,Schofield Christopher J.1ORCID

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK

2. Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK

3. MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital/Headley Way, Oxford, OX3 9DS, UK

4. Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK

Abstract

Asparagine levels are reduced in patients with diabetes and alcoholism. A plausible mechanism is that aldehydes elevated in these diseases react with the N-terminal cysteine of asparagine synthetase B, so inhibiting asparagine production.

Funder

Wellcome Trust

Cancer Research UK

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3