Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants

Author:

Velásquez-Jiménez Dafne1,Corella-Salazar Diana A.1,Zuñiga-Martínez B. Shain1ORCID,Domínguez-Avila J. Abraham2ORCID,Montiel-Herrera Marcelino3ORCID,Salazar-López Norma J.14ORCID,Rodrigo-Garcia Joaquín5ORCID,Villegas-Ochoa Mónica A.1ORCID,González-Aguilar Gustavo A.1ORCID

Affiliation:

1. Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico

2. Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico

3. Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, 83000 Hermosillo, Sonora, Mexico

4. Universidad Autónoma de Baja California, Facultad de Medicina de Mexicali, Dr. Humberto Torres Sanginés S/N, Centro Cívico, Mexicali, Baja California 21000, Mexico

5. Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del Pronaf y Estocolmo s/n, 32310 Ciudad Juárez, Chihuahua, Mexico

Abstract

The ability of phenolic compounds to cross the blood–brain barrier and reach the central nervous system is discussed. There are knowledge gaps that require additional experimentation, such as inconclusive transport mechanisms and lack of human data.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Reference91 articles.

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4. E.Chin and E.Goh , Chapter 9 - Blood–brain barrier on a chip , in Methods in Cell Biology , ed. J. Doh , D. Fletcher and M. Piel , Academic Press , 2018 , vol. 146 , pp. 159–182

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