Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

Author:

Brown Jacquelyn A.12,Pensabene Virginia1,Markov Dmitry A.12,Allwardt Vanessa3ORCID,Neely M. Diana4,Shi Mingjian5,Britt Clayton M.3,Hoilett Orlando S.3ORCID,Yang Qing3,Brewer Bryson M.6ORCID,Samson Philip C.12,McCawley Lisa J.127,May James M.8,Webb Donna J.5,Li Deyu6,Bowman Aaron B.4ORCID,Reiserer Ronald S.23,Wikswo John P.1238

Affiliation:

1. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA

2. Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee 37235, USA

3. Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA

4. Department of Neurology, Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Vanderbilt Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37232, USA

5. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA

6. Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA

7. Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA

8. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37235, USA

Funder

National Institute of Environmental Health Sciences (NIEHS)

National Center for Advancing Translational Sciences (NCATS)

Publisher

AIP Publishing

Subject

Condensed Matter Physics,General Materials Science,Fluid Flow and Transfer Processes,Colloid and Surface Chemistry,Biomedical Engineering

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