The ACE2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion-Reference-Cited by-同舟云学术

The ACE2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion

Published:2023 Issue:25 Volume:14 Page:6997-7004
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cervantes Marcos¹,Hess Tobin¹,Morbioli Giorgio G.¹^ORCID,Sengar Anjali¹,Kasson Peter M.¹²^ORCID

Affiliation:

1. Departments of Molecular Physiology and Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA

2. Science for Life Laboratory and Department of Molecular and Cellular Biology, Uppsala University, Uppsala, SE 75123, USA

Abstract

DNA-lipid tethers can replace ACE2 receptor attachment for SARS-CoV-2 entry. An attachment factor and protease are sufficient for membrane fusion, but ACE2 added in trans speeds up fusion kinetics.

Funder

Global Infectious Diseases Institute, University of Virginia

Knut och Alice Wallenbergs Stiftelse

Commonwealth Health Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06967A

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