Ligand-conjugated quantum dots for fast sub-diffraction protein tracking in acute brain slices

Author:

Thal Lucas B.12345ORCID,Mann Victor R.16748ORCID,Sprinzen David923410,McBride James R.123411ORCID,Reid Kemar R.123411,Tomlinson Ian D.1234ORCID,McMahon Douglas G.10234ORCID,Cohen Bruce E.8127413ORCID,Rosenthal Sandra J.12345ORCID

Affiliation:

1. Department of Chemistry

2. Vanderbilt University

3. Nashville

4. USA

5. Vanderbilt Institute of Chemical Biology

6. University of California

7. Berkeley

8. The Molecular Foundry

9. Neuroscience Graduate Program

10. Department of Biological Sciences

11. Vanderbilt Institute of Nanoscale Science and Engineering

12. Lawrence Berkeley National Laboratory

13. Molecular Biophysics and Bioimaging Division

Abstract

We introduce a quantum dot probe for high-spatiotemporal imaging in brain tissue and reassess the utility of commercially available probes.

Funder

National Institutes of Health

U.S. Department of Energy

National Institute of Mental Health

Vanderbilt University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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