Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking-Reference-Cited by-同舟云学术

Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking

Published:2003-10-17 Issue:5644 Volume:302 Page:442-445
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dahan Maxime¹²,Lévi Sabine¹²,Luccardini Camilla¹²,Rostaing Philippe¹²,Riveau Béatrice¹²,Triller Antoine¹²

Affiliation:

1. Laboratoire Kastler Brossel, CNRS UMR 8552, Ecole Normale Supérieure and Université Pierre et Marie Curie, 24 rue Lhomond, 75005 Paris, France.

2. Biologie Cellulaire de la Synapse, INSERM U497, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France.

Abstract

Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and analyze their lateral dynamics in the neuronal membrane of living cells for periods ranging from milliseconds to minutes. We characterized multiple diffusion domains in relation to the synaptic, perisynaptic, or extrasynaptic GlyR localization. The entry of GlyRs into the synapse by diffusion was observed and further confirmed by electron microscopy imaging of QD-tagged receptors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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