Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016-Reference-Cited by-同舟云学术

Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

Published:2016 Issue:86 Volume:6 Page:82716-82720
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Okusu Satoshi¹²³⁴,Hirano Kazuki¹²³⁴,Yasuda Yoshimasa¹²³⁴,Tokunaga Etsuko¹²³⁴,Shibata Norio¹²³⁴

Affiliation:

1. Department of Nanopharmaceutical Sciences & Department of Frontier Materials

2. Nagoya Institute of Technology

3. Nagoya 466-8555

4. Japan

Abstract

Flow trifluoromethylation of carbonyl compounds using the Ruppert–Prakash reagent, Me₃SiCF₃ is disclosed including enantioselective trifluoromethylation. Synthesis of pharmaceuticals, efavirenz and HSD-016 were achieved by this flow method.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA19790F

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