Synthesis of BACE1 Inhibitors E2609/E2071 via Oxime–Olefin Cycloaddition Following a Process Risk Mitigation Strategy-Reference-Cited by-同舟云学术

Synthesis of BACE1 Inhibitors E2609/E2071 via Oxime–Olefin Cycloaddition Following a Process Risk Mitigation Strategy

Published:2021-08-03 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kim Dae-Shik¹^ORCID,Yoshizawa Kazuhiro²,Mitasev Branko¹,Schnaderbeck Matthew¹,Zhang Huiming¹,Omori Masayuki²,Kayano Akio²,Nagai Mitsuo²,Wakasugi Kazunori²,Watanabe Yuzo²,Benayoud Farid¹,Suzuki Yuichi³,Motoki Takafumi³^ORCID,Kaneko Toshihiko³,Takaishi Mamoru³,Ishida Tasuku³,Takeda Kunitoshi³,Kita Yoichi³,Yamamoto Noboru⁴,Khan Afzal⁴,Dimopoulos Paschalis⁴,Farthing Christopher N.⁴,Hall Adrian⁴^ORCID,Chanda Arani¹,Lu Lily¹,Bracke Markus¹,Fang Francis G.¹

Affiliation:

1. Eisai Incorporated, 35 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States

2. API Research Japan, Pharmaceutical Science & Technology Core Function Units, Medicine Creation Center, Eisai Company, Limited, 22-Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan

3. Neurology Business Group Eisai Tsukuba Research Laboratories, Tokodai, 5-1-3 Tsukuba-shi, Ibaraki 300-2635, Japan

4. Eisai Europe Limited, EMEA Knowledge Centre, Mosquito Way, Hatfield Hertfordshire AL10 9SN, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00223

Reference33 articles.

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2. BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

3. aSuzuki, Y.; Motoki, T.; Kaneko, T.; Takaishi, M.; Ishida, T.; Kita, Y.; Takeda, K.; Yamamoto, N.; Khan, A.; Dimopoulos, P. Fused aminodihydrothiazine derivatives. Patent WO200991016A1, 2009.

4. S4‐04‐01: CSF amyloid lowering in human volunteers after 14 days’ oral administration of the novel BACE1 inhibitor E2609

5. A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

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