An endoplasmic reticulum-targeting iridium(<scp>iii</scp>) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment-Reference-Cited by-同舟云学术

An endoplasmic reticulum-targeting iridium(iii) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment

Published:2023 Issue:18 Volume:10 Page:5278-5291
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Rong Yi¹,Fan Zhongxian²,Yu Zhijie¹,Wei Li²,Shen Han¹,Huang Huaiyi²^ORCID,Hao Xiaojuan¹³,Zhao Zizhuo⁴,Wang Jinquan¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery, School of Bioscience and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China

2. School of Pharmaceutical Science (Shenzhen), Shen Zhen Campus of Sun Yat-Sen University, Shenzhen, 518107, P. R. China

3. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, P. R. China

4. Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510275, P. R. China

Abstract

IrC induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling the tumor microenvironment in mice.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Science, Technology and Innovation Commission of Shenzhen Municipality

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)