PD-1 or PD-L1 Blockade Adds Little to Combination of BRAF and MEK Inhibition in the Treatment of BRAF V600–Mutated Melanoma
Author:
Affiliation:
1. Memorial Sloan Kettering Cancer Center, New York, NY
2. Weill Cornell Medical College, New York, NY
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
https://ascopubs.org/doi/pdfdirect/10.1200/JCO.21.02801
Reference13 articles.
1. Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics
2. BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma
3. Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma
4. Immunological consequences of selective BRAF inhibitors in malignant melanoma
5. Inhibition of both BRAF and MEK in BRAFV600E mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties
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