α-Trifluoromethylated tertiary homoallylic amines: diastereoselective synthesis and conversion into β-aminoesters, γ- and δ-aminoalcohols, azetidines and pyrrolidines-Reference-Cited by-同舟云学术

α-Trifluoromethylated tertiary homoallylic amines: diastereoselective synthesis and conversion into β-aminoesters, γ- and δ-aminoalcohols, azetidines and pyrrolidines

Published:2017 Issue:45 Volume:15 Page:9696-9709
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Grellepois Fabienne¹²³⁴⁵^ORCID,Ben Jamaa Abdelkhalek¹²³⁴⁵,Saraiva Rosa Nathalie¹²³⁴⁵

Affiliation:

1. Université de Reims Champagne-Ardenne

2. Institut de Chimie Moléculaire de Reims

3. CNRS UMR 7312

4. UFR des Sciences Exactes et Naturelles

5. 51687 Reims Cedex 2

Abstract

The diastereoselective synthesis and the functionalization of homoallylic tertiary carbinamines containing a tetrasubstituted carbon stereocentre bearing a trifluoromethyl group are described.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02506H

Reference82 articles.

1. Fluorine in Medicinal Chemistry

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

3. Understanding organofluorine chemistry. An introduction to the C–F bond