Tandem synthesis of 4-aminoxanthones is controlled by a water-assisted tautomerization: a general straightforward reaction-Reference-Cited by-同舟云学术

Tandem synthesis of 4-aminoxanthones is controlled by a water-assisted tautomerization: a general straightforward reaction

Published:2019 Issue:6 Volume:17 Page:1410-1422
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bornadiego Ana¹²³⁴⁵,Díaz Jesús¹²³⁴⁵^ORCID,Marcos Carlos F.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Bioorganic Chemistry & Membrane Biophysics (L.O.B.O.)

2. School of Veterinary Sciences

3. University of Extremadura

4. 10071 Cáceres

5. Spain

Abstract

Iminolactone-aminofuran tautomerization is the rate-determining step in the multicomponent synthesis of xanthones from 3-carbonylchromones, isocyanides and dienophiles.

Funder

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02527D

Reference50 articles.

1. Xanthones from Fungi, Lichens, and Bacteria: The Natural Products and Their Synthesis

2. Xanthone Derivatives: New Insights in Biological Activities

3. Structure–activity relationships of diverse xanthones against multidrug resistant human tumor cells

4. Studies on gambogic acid (IV): Exploring structure–activity relationship with IκB kinase-beta (IKKβ)

5. Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells

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