An approach to unsymmetrical 3,3′-diindolylmethanes through Pd-catalyzed cascade Heck cyclization of allenamides and o-ethynylanilines-Reference-Cited by-同舟云学术

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An approach to unsymmetrical 3,3′-diindolylmethanes through Pd-catalyzed cascade Heck cyclization of allenamides and o-ethynylanilines

Published:2021 Issue:8 Volume:8 Page:1783-1788
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Guo Songjin¹²³⁴⁵,Chen Jiayi¹²³⁴⁵,Yi Mingjun¹²³⁴⁵,Dong Liuli¹²³⁴⁵,Lin Aijun¹²³⁴⁵^ORCID,Yao Hequan¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry

2. School of Pharmacy

3. China Pharmaceutical University

4. Nanjing

5. P. R. China

Abstract

A highly efficient synthesis of unsymmetrical 3,3′-diindolylmethanes has been developed by palladium-catalyzed cascade Heck/cyclization reaction.

Funder

National Natural Science Foundation of China

State Key Laboratory of Natural Medicines

National Science and Technology Major Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01539C

Reference59 articles.

1. 3,3′-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway

2. Effect of Oral Administration of 3,3′-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice

3. Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells

4. Hybrids of coumarin–indole: design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models

5. Synergistic Anticancer Activity of Capsaicin and 3,3′-Diindolylmethane in Human Colorectal Cancer

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