Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells-Reference-Cited by-同舟云学术

Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells

Published:2012-02-09 Issue:4 Volume:55 Page:1583-1592
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Wen-Shan¹²,Wang Chie-Hong¹³,Ko Shengkai¹⁴,Chang Tzu Ting¹,Jen Ya Ching¹,Yao Ching-Fa⁴,More Shivaji V.¹,Jao Shu-Chuan⁵

Affiliation:

1. Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan

2. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan

3. Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan

4. Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan

5. Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2013425

Reference53 articles.

1. Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells

2. Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol

3. Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

4. Indole-3-carbinol as a chemopreventive and anti-cancer agent

5. The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing

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