Modified diterpenoids from the tuber of Icacina oliviformis as protein tyrosine phosphatase 1B inhibitors

Author:

Zhou Junfei12345ORCID,Wu Zhenlong12345,Guo Brian12345,Sun Meng12345,Onakpa Monday M.678910,Yao Guangmin1112131415ORCID,Zhao Ming162171819,Che Chun-Tao12345

Affiliation:

1. Department of Pharmaceutical Sciences

2. College of Pharmacy

3. University of Illinois at Chicago

4. Chicago

5. USA

6. Department of Veterinary Pharmacology and Toxicology

7. Faculty of Veterinary Medicine

8. University of Abuja

9. Abuja 920001

10. Nigeria

11. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation

12. School of Pharmacy

13. Tongji Medical College

14. Huazhong University of Science and Technology

15. Wuhan 430030

16. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization

17. Nanjing University of Chinese Medicine

18. Nanjing 210023

19. People's Republic of China

Abstract

Two modified diterpenoids featuring a novel 4,12-dioxatetracyclo[8.6.0.02,7.010,14]hexadecane core, together with a 3,4-seco-pimarane, a 3,4-seco-cleistanthane, and eight pimarane derivatives were isolated from the tuber of Icacina oliviformis.

Funder

National Institutes of Health

University of Illinois at Chicago

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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