Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation-Reference-Cited by-同舟云学术

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation

Published:2022 Issue:39 Volume:13 Page:11533-11539
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chrzastek Alina¹^ORCID,Thanasi Ioanna A.¹,Irving James A.²^ORCID,Chudasama Vijay¹^ORCID,Baker James R.¹^ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, UK

2. UCL Respiratory, Rayne Institute, University College London, WC1E 6JF, London, UK

Abstract

Here we describe the first examples of a new class of disulfide bridging reagents, designed to insert a ‘stable-labile’ linkage; which can then be exploited to generate dual functional antibody fragment conjugates.

Funder

University College London

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC04531A

Reference43 articles.

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5. A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics

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