Regioselective difunctionalization of pyridines via 3,4-pyridynes-Reference-Cited by-同舟云学术

Regioselective difunctionalization of pyridines via 3,4-pyridynes

Published:2021 Issue:17 Volume:12 Page:6143-6147
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Heinz Benjamin¹²³⁴,Djukanovic Dimitrije¹²³⁴,Filipponi Paolo⁵⁶⁷,Martin Benjamin⁵⁶⁷,Karaghiosoff Konstantin¹²³⁴,Knochel Paul¹²³⁴^ORCID

Affiliation:

1. Ludwig-Maximilians-Universität München

2. Department Chemie

3. 81377 Munich

4. Germany

5. Novartis Pharma AG, Chemical Development

6. 4002 Basel

7. Switzerland

Abstract

A regioselective 3,4-difunctionalization of pyridines was performed. Lithiation and transmetalation with arylmagnesiums gave 3,4-pyridyne intermediates. Addition of magnesium species led to 3-pyridylmagnesiums which were quenched with electrophiles.

Funder

Novartis Pharma

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01208H

Reference84 articles.

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3. Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B

4. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

5. Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists

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