Regioselective difunctionalization of pyridines via 3,4-pyridynes
Author:
Affiliation:
1. Ludwig-Maximilians-Universität München
2. Department Chemie
3. 81377 Munich
4. Germany
5. Novartis Pharma AG, Chemical Development
6. 4002 Basel
7. Switzerland
Abstract
A regioselective 3,4-difunctionalization of pyridines was performed. Lithiation and transmetalation with arylmagnesiums gave 3,4-pyridyne intermediates. Addition of magnesium species led to 3-pyridylmagnesiums which were quenched with electrophiles.
Funder
Novartis Pharma
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01208H
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