Fingerprinting of falsified artemisinin combination therapies via direct analysis in real time coupled to a compact single quadrupole mass spectrometer

Author:

Bernier Matthew C.1234,Li Frederick564,Musselman Brian564,Newton Paul N.7891011,Fernández Facundo M.1234

Affiliation:

1. School of Chemistry and Biochemistry

2. Georgia Institute of Technology

3. Atlanta

4. USA

5. Ionsense Inc.

6. Saugus

7. Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit (LOMWRU)

8. Laos and Worldwide Antimalarial Resistance Network

9. Centre for Tropical Medicine & Global Health

10. University of Oxford

11. UK

Abstract

Using portable single-quadrupole DART-MS technology, suspect pharmaceuticals can be rapidly and efficiently analyzed providing detailed information on their true origin.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference45 articles.

1. World Health Organization , 2016. Fact Sheet No. 94, http://www.who.int/mediacentre/factsheets/fs094/en/, accessed April 20th, 2016

2. World Health Organization , Top Ten Causes of Death 2012. Fact Sheet No. 310, http://www.who.int/mediacentre/factsheets/fs310/en/, accessed April 20th, 2016

3. Estimated Under-Five Deaths Associated with Poor-Quality Antimalarials in Sub-Saharan Africa

4. Poor quality vital anti-malarials in Africa - an urgent neglected public health priority

5. A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR – implications for therapeutic failure and drug resistance

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