Molecular docking assisted 3D-QSAR study of benzylidene-2,4-thiazolidinedione derivatives as PTP-1B inhibitors for the management of Type-2 diabetes mellitus
Author:
Affiliation:
1. School of Pharmaceutical Sciences
2. Guru Ghasidas Vishwavidyalaya (A Central University)
3. Bilaspur-495 009
4. India
Abstract
An integrated molecular docking assisted 3D-QSAR study was performed on benzylidene-2,4-thiazolidinediones to identify spatial fingerprints for designing PTP-1B inhibitors.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA03067J
Reference38 articles.
1. PROTEIN TYROSINE PHOSPHATASE 1B (PTP1B) IN OBESITY AND TYPE 2 DIABETES
2. Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells
3. Protein tyrosine phosphatase 1B inhibitors for diabetes
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