Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA-Reference-Cited by-同舟云学术

Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA

Published:2023 Issue:21 Volume:13 Page:14631-14640
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mohamed Asmaa H.¹,Mostafa Sara M.¹^ORCID,Aly Ashraf A.¹^ORCID,Hassan Alaa A.¹,Osman Esraa M.¹,Nayl AbdElAziz A.²,Brown Alan B.³^ORCID,Abdelhafez Elshimaa M. N.⁴^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt

2. Department of Chemistry, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia

3. Chemistry Department, Florida Institute of Technology, Melbourne, FL, USA

4. Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Abstract

In an attempt to develop effective and safe antibacterial agents, thiazinanones bearing the quinolone scaffold were prepared by reaction of the corresponding (quinolinylmethylene)hydrazinecarbothioamides with 2,3-diphenylcycloprop-2-enone.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01721D

Reference45 articles.

1. Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents

2. Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents

3. 4-Thiazolidinone – A biologically active scaffold

4. Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors

5. A DIC mediated expeditious small library synthesis and biological activity of thiazolidin-4-one and 1,3-thiazinan-4-one derivatives

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