Lewis base-catalyzed cascade [4 + 2]-annulation reaction of <i>N</i>-alkoxy acrylamides and acyl isothiocyanates: facile access to 2-imino-1,3-thiazinone derivatives-Reference-Cited by-同舟云学术

Lewis base-catalyzed cascade [4 + 2]-annulation reaction of N-alkoxy acrylamides and acyl isothiocyanates: facile access to 2-imino-1,3-thiazinone derivatives

Published:2023 Issue:46 Volume:21 Page:9200-9209
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Zhaoxue¹,Tian Ge¹,Shi Yuying¹,Liu Wanxing²,Xu Xiangdong³,Li Xiaojing¹^ORCID,Wu Lingang¹^ORCID,Xie Lei¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng Key Laboratory of Quality Control and Pharmacodynamic Evaluation of Ganoderma lucidum, Liaocheng 252000, Shandong, P. R. China

2. The Non-Public Enterprise Service Center of Liaocheng, Liaocheng 252000, Shandong, P. R. China

3. Liaocheng Inspection and Testing Center, Liaocheng 252000, Shandong, P. R. China

Abstract

A Lewis base-catalyzed cascade aza-nucleophilic addition/thio-Michael addition reaction of N-alkoxy acrylamides with acyl isothiocyanates has been developed to afford various 2-imino-1,3-thiazinone derivatives in 40–97% yields.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01440A

Reference44 articles.

1. Synthesis and Antimicrobial Activity of Novel Pyrazolo[3,4-b]quinoline Derivatives