Et3N-catalyzed [3 + 2] annulation reaction of <i>β</i>-oxo-acrylamides with diethyl 2-oxomalonates: facile access to oxazolidin-4-one derivatives-Reference-Cited by-同舟云学术

Et3N-catalyzed [3 + 2] annulation reaction of β-oxo-acrylamides with diethyl 2-oxomalonates: facile access to oxazolidin-4-one derivatives

Published:2024-07 Issue:7 Volume:53 Page:
ISSN:0366-7022
Container-title:Chemistry Letters
language:en
Short-container-title:

Author:

Wu Lingang¹²³^ORCID,Guan Baochuan⁴,Wang Zhaoxue¹²,Xie Lei¹²³

Affiliation:

1. School of Chemistry and Chemical Engineering, Liaocheng University, No. 1 Hunan Road, Dongchangfu District, Liaocheng 252000, Shandong Province, China

2. School of Pharmaceutical Sciences, Liaocheng University, No. 1 Hunan Road, Dongchangfu District, Liaocheng 252000, Shandong Province, China

3. School of Chemistry and Chemical Engineering, University of Jinan, No. 336 Nanxinzhuang West Road, Shizhong District, Jinan 252022, Shandong Province, China

4. Research and Development, Maxunitech Inc., No. 603 Bin Kang Road, Bin Jiang District, Hangzhou 310051, Zhejiang Province, China

Abstract

Abstract A new and effective method for the [3 + 2] annulation of β-oxo-acrylamides with diethyl 2-oxomalonate, catalyzed by NEt3, has been developed to be carried out under mild reaction conditions. This approach offers a direct route to synthesize oxazolidin-4-one derivatives with yields ranging from 58% to 76%. The process is notable for being highly atom-efficient and operationally simple.

Funder

Natural Science Foundation of Shandong Province

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/chemlett/article-pdf/53/7/upae116/58391273/upae116.pdf

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