A review of sample preparation methods for quantitation of small-molecule analytes in brain tissue by liquid chromatography tandem mass spectrometry (LC-MS/MS)

Author:

Li Pei1234,Bartlett Michael G.1234

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences

2. College of Pharmacy

3. The University of Georgia

4. Athens, USA

Abstract

Concentration measurements are one of the most important and fundamental approaches in preclinical and clinical studies of small-molecule drugs, metabolites and biomarkers, providing important information based on the concentration of target analytes in biological fluids or tissues.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference143 articles.

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2. Peer Reviewed: Sample Preparation for LC/MS/MS: Analyzing Biological and Environmental Samples

3. R. S. Frackowiak , K. J.Friston , C. D.Frith , R. J.Dolan , J. C.Mazziotta and M.Hallett , Human Brain Function (1st Edition) , Academic Press, New York, NY, 1997

4. B. W. Agranoff , J. A.Benjamins and A. K.Hajra , in Molecular, Cellular and Medical Aspects , ed. G. J. Siegel , B. W. Agranoff , R. W. Albers et al. , Lippincott-Raven , Philadelphia , 6th edn, 1999

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