Expanding the known structure space for RNA binding: a test of 2,5-diketopiperazine-Reference-Cited by-同舟云学术

Expanding the known structure space for RNA binding: a test of 2,5-diketopiperazine

Published:2022 Issue:3 Volume:20 Page:606-612
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Arévalo Diego M.¹^ORCID,Anokhina Viktoriya S.²,Swart Oliver L. R.¹,Miller Benjamin L.²³^ORCID

Affiliation:

1. Department of Chemistry, University of Rochester, Rochester, NY 14642, USA

2. Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA

3. Departments of Dermatology, University of Rochester, Rochester, NY 14642, USA

Abstract

A compound incorporating a 2,5-diketopiperazine substructure is able to selectively bind an RNA critical to the process of ribosomal frameshifting in HIV.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB01976G

Reference35 articles.

1. An update on RNA-targeting therapies for neuromuscular disorders

2. From microRNA functions to microRNA therapeutics: Novel targets and novel drugs in breast cancer research and treatment

3. Controlled delivery of antisense oligonucleotides: a brief review of current strategies

4. Antisense Oligonucleotide Therapies

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