An isotopic probe to follow the stereochemical course of dehydratase reactions in polyketide and fatty acid biosynthesis-Reference-Cited by-同舟云学术

An isotopic probe to follow the stereochemical course of dehydratase reactions in polyketide and fatty acid biosynthesis

Published:2022 Issue:10 Volume:9 Page:2714-2720
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yin Zhiyong¹,Liebhart Elisa²,Stegmann Evi²,Brötz-Oesterhelt Heike²^ORCID,Dickschat Jeroen S.¹^ORCID

Affiliation:

1. Kekulé-Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany

2. Interfaculty Institute of Microbiology and Infection Medicine, Deptartment of Microbial Bioactive Compounds, Auf der Morgenstelle 28, 72076 Tübingen, Germany

Abstract

Four stereoisomeric and isotopically labelled probes that are suitable to easily follow the stereochemical course of dehydratases have been synthesised.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00272H

Reference32 articles.

1. Polyketide stereocontrol: a study in chemical biology

2. Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases

3. Stereochemical course of dehydration catalysed by the yeast fatty acid synthetase

4. Stereochemistry of the reactions catalyzed by chicken liver fatty acid synthase

5. Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase

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