Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies-Reference-Cited by-同舟云学术

Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies

Published:2015 Issue:38 Volume:13 Page:9862-9871
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Gopi Elumalai¹²³⁴,Kumar Tarun¹²³⁴,Menna-Barreto Rubem F. S.⁵⁶⁷⁸,Valença Wagner O.⁹¹¹⁰¹¹⁸,da Silva Júnior Eufrânio N.⁹¹¹⁰¹¹⁸,Namboothiri Irishi N. N.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Bombay

3. Mumbai 400 076

4. India

5. Oswaldo Cruz Institute

6. FIOCRUZ

7. Rio de Janeiro

8. Brazil

9. Institute of Exact Sciences

10. Federal University of Minas Gerais

11. Belo Horizonte

Abstract

One-pot cascade reactions of amidines with nitroallylic acetates and α-bromonitroalkenes provide functionalized imidazoles that exhibit trypanocidal activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01444A

Reference130 articles.

1. Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from β-lapachone

2. Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study

3. Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from β-lapachone

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