Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions-Reference-Cited by-同舟云学术

Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions

Published:2021 Issue:39 Volume:11 Page:24466-24473
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mohlala Reagan L.¹²³⁴⁵,Coyanis E. Mabel¹²³⁴,Fernandes Manuel A.⁵⁶⁷⁴^ORCID,Bode Moira L.⁵⁶⁷⁴^ORCID

Affiliation:

1. Advanced Materials Division

2. Mintek

3. Randburg

4. South Africa

5. Molecular Sciences Institute

6. University of the Witwatersrand

7. PO Wits

Abstract

Reaction of benzimidazole derivatives with an isocyanide and acetone led to tricyclic benzodiazepine derivatives or dihydroquinoxalines depending on the nature of the substituents R¹ and R².

Funder

National Research Foundation

Mintek

University of the Witwatersrand, Johannesburg

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04444C

Reference44 articles.

1. Water-Medium and Solvent-Free Organic Reactions over a Bifunctional Catalyst with Au Nanoparticles Covalently Bonded to HS/SO3H Functionalized Periodic Mesoporous Organosilica

2. Solvent-Free and Catalysts-Free Chemistry: A Benign Pathway to Sustainability

3. Chemistry and Biology Of Multicomponent Reactions

4. Ugi Four-component Reaction (U-4CR) Under Green Conditions Designed for Undergraduate Organic Chemistry Laboratories

5. A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridines

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A facile and efficient one-pot 3-component reaction (3-CR) method for the synthesis of thiazine-based heterocyclic compounds using zwitterion adduct intermediates;Physical Sciences Reviews;2024-05-16

2. Water Extract of Onion Catalyst: A Sustainable Approach for the Synthesis of 4-Substituted 1,5-Benzodiazepine Derivatives via an In Situ Generated Enaminones;Current Organocatalysis;2023-11-10

3. Advances in Isocyanide‐Based Multicomponent Synthesis of Quinoxaline Scaffolds;ChemistrySelect;2023-09-07

4. Advancements in Synthesis and Application of 1,5-benzodiazepines a Privileged Scaffold with a Wide Scope of Bioactivities;Current Organic Chemistry;2023-09

5. Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro;Bioorganic Chemistry;2023-06