Affiliation:
1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, Uttar Pradesh
226002, India
Abstract
Abstract:
A heterocyclic scaffold-like benzodiazepine (BZD) has shown a wide variety of
medicinal values and utmost importance in pharmaceutical industries. BZDs are sevenmembered
heterocyclic molecules and have many structural isomers, such as 1,2; 1,3; 1,4;
1,5; 2,4; and 2,3. Among these BZDs, 1,5-BZDs play a significant role in pharmacological
activities like anti-anxiety, anti-convulsion, antimicrobial, sedative, and hypnotics. These
moieties have been the subject of extensive research with the development of synthetic
methods, leading to the generation of numerous useful molecules over the last few decades.
Therefore, we have further explored the recent literature on the 1,5-BZDs synthesis and associated
biological activities to expand the role and utility of newer 1.5-BZDs. This review
article gives a recent and insightful thought about the synthetic methods and therapeutic
applications of 1,5-BZDs.
Publisher
Bentham Science Publishers Ltd.
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