An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase-Reference-Cited by-同舟云学术

An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

Published:2020 Issue:3 Volume:56 Page:399-402
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Vincent Amandine¹²³⁴⁵,Fores Jennifer Rodon¹²³⁴⁵,Tauziet Elodie¹²³⁴⁵,Quévrain Elodie¹²³⁴⁵,Dancs Ágnes⁶⁷⁸⁹¹⁰,Conte-Daban Amandine¹¹¹²¹⁰,Bernard Anne-Sophie¹²³⁴⁵,Pelupessy Philippe¹²³⁴⁵^ORCID,Coulibaly Koudedja¹²³⁴⁵,Seksik Philippe¹³¹⁴¹⁵¹⁶¹⁷,Hureau Christelle¹¹¹²¹⁰^ORCID,Selmeczi Katalin⁶⁷⁸⁹¹⁰^ORCID,Policar Clotilde¹²³⁴⁵^ORCID,Delsuc Nicolas¹²³⁴⁵^ORCID

Affiliation:

1. Laboratoire des Biomolécules

2. LBM

3. Département de Chimie

4. Ecole Normale Supérieure

5. PSL University

6. Laboratoire Lorrain de Chimie Moléculaire

7. L2CM UMR 7053 Université de Lorraine – CNRS

8. Faculté des Sciences et Technologies

9. 54506 Vandoeuvre-lès-Nancy cedex

10. France

11. CNRS, LCC (Laboratoire de Chimie de Coordination)

12. 31077 Toulouse Cedex 4

13. Centre de Recherche Saint Antoine

14. INSERM

15. UMRS 938

16. Metabolism-Inflammation Department

17. 75012 Paris

Abstract

A strategy combining combinatorial chemistry and an activity-based screening leads to the development of a peptidyl catalytic drug that reduces the oxidative stress in cellular models.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC07920C

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4. Rationally designed mimics of antioxidant manganoenzymes: Role of structural features in the quest for catalysts with catalase and superoxide dismutase activity

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