Molecular obesity, potency and other addictions in drug discovery-Reference-Cited by-同舟云学术

Molecular obesity, potency and other addictions in drug discovery

Published:2011 Issue:5 Volume:2 Page:349-355
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Hann Michael M.¹²³⁴

Affiliation:

1. Computational and Structural Chemistry

2. GSK Medicines Research Centre

3. Stevenage

4. UK

Abstract

Molecular Obesity is the tendency for lead optimisation to yield candidate molecules that are unfit for their continued survival towards becoming a drug. Reasons for this and other issues are discussed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2011/MD/C1MD00017A

Reference31 articles.

1. How to improve R&D productivity: the pharmaceutical industry's grand challenge

2. P. Ball . Nature News , Online 5th April 2010, http://www.nature.com/news/2010/100405/full/news.2010.157.html

3. A. W. Lo , M. T.Mueller , Social Sciences Review Network , March 12, 2010 , http://ssrn.com/abstract=1563882

4. S. H. Kellert , In the Wake of Chaos: Unpredictable Order in Dynamical Systems , University of Chicago Press , 1993

5. Can the pharmaceutical industry reduce attrition rates?

Cited by 314 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Thermodynamic characteristics of multi-component crystals: Experimental evaluation, prediction and relationship with crystal parameters;Journal of Molecular Liquids;2024-10

2. In silico ADMET and DFT analysis of methoxy substituted curcumin derivatives;Inorganic Chemistry Communications;2024-10

3. Novel imidazo[2,1-b]thiazoles and imidazo[1,2-a]pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and biological evaluations;Bioorganic Chemistry;2024-10

4. Chemoinformatic Characterization of NAPROC-13: A Database for Natural Product ¹³C NMR Dereplication;Journal of Natural Products;2024-09-13

5. Spaces of mathematical chemistry;Theory in Biosciences;2024-09-11