Fluorinated and [18F]fluorinated morphinan based opioid ligands

Author:

Sandulenko Irina V.1234,Ambartsumyan Asmik A.1234ORCID,Moiseev Sergey K.1234ORCID

Affiliation:

1. Institute of Organoelement Compounds

2. Russian Academy of Sciences

3. Moscow 119991

4. Russia

Abstract

Fluorinated 4,5α-epoxymorphinans, opioid ligands for drug development and PET imaging of opioid receptors using [18F]tracers, are reviewed.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference104 articles.

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2. ORL1, a novel member of the opioid receptor family

3. Update 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

4. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

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