C(21)-Di- and monofluorinated scaffold for thevinol/orvinol-based opioid receptor ligands-Reference-Cited by-同舟云学术

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C(21)-Di- and monofluorinated scaffold for thevinol/orvinol-based opioid receptor ligands

Published:2023 Issue:45 Volume:21 Page:9091-9100
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zelentsova Maria V.¹^ORCID,Sandulenko Irina V.¹,Ambartsumyan Asmik A.¹^ORCID,Danshina Anastasia A.¹²,Moiseev Sergey K.¹^ORCID

Affiliation:

1. A.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova, 28, bld. 1, Moscow, 119334, Russia

2. Moscow Institute of Physics and Technology (National Research University), Institutskiy per., 9, Dolgoprudny, Moscow Region, 141700, Russia

Abstract

Preparations of 21,21-difluorothevinone, 21-fluorothevinone, and 21,21-difluorothevinols, precursors of opioid receptor ligands, are reported.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01577G

Reference66 articles.

1. Diels–Alder Adducts of Morphinan-6,8-Dienes and Their Transformations

2. Buprenorphine and Related Orvinols

3. The Orvinols and Related Opioids - High Affinity Ligands with Diverse Efficacy Profiles

4. Applications of Fluorine in Medicinal Chemistry

5. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

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