Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides-Reference-Cited by-同舟云学术

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

Published:2018 Issue:6 Volume:54 Page:658-661
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bouzada David¹²³⁴⁵,Salvadó Iria¹²³⁴⁶,Barka Ghofrane¹²³⁴⁶,Rama Gustavo¹²³⁴⁶,Martínez-Costas José¹²³⁴⁷,Lorca Romina⁸⁹¹⁰⁴,Somoza Álvaro⁸⁹¹⁰⁴^ORCID,Melle-Franco Manuel¹¹¹²¹³¹⁴,Vázquez M. Eugenio¹²³⁴⁵^ORCID,Vázquez López Miguel¹²³⁴⁶^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS)

2. Universidade de Santiago de Compostela

3. 15782 Santiago de Compostela

4. Spain

5. Departamento de Química Orgánica

6. Departamento de Química Inorgánica

7. Departamento de Bioquímica y Biología Molecular

8. Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia)

9. Cantoblanco

10. 28049 Madrid

11. Ciceco – Aveiro Institute of Materials, University of Aveiro

12. Campus Universitario de Santiago

13. Aveiro

14. Portugal

Abstract

We demonstrate that both the R₈ functionalization and its interplay with the ancillary ligand have and an important role in the G-quadruplex recognition process by Ru(dppz) metallopeptides.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

European Regional Development Fund

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

Centro de Investigação em Materiais Cerâmicos e Compósitos

Fundación Científica Asociación Española Contra el Cáncer

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C7CC08286J

Reference42 articles.

1. G-quadruplex nucleic acids as therapeutic targets

2. The application of DNA and RNA G-quadruplexes to therapeutic medicines

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4. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

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