Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA-Reference-Cited by-同舟云学术

Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA

Published:2023 Issue:7 Volume:4 Page:486-493
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Rodriguez Jessica¹²^ORCID,Battistini Federica²³,Learte-Aymamí Soraya¹^ORCID,Orozco Modesto²³,Mascareñas José L.¹^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela Rúa Jenaro de la Fuente s/n, 15782, Santiago de Compostela, Spain

2. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10-12, 08028 Barcelona, Spain

3. Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain

Abstract

We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules linked by an AT-hook peptide.

Funder

Ministerio de Ciencia e Innovación

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

Instituto de Salud Carlos III

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00053B

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4. The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

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